These molecules include modified FGF21 as well as agonistic antibodies against the receptor for FGF21, namely the complex of FGF receptor 1 (FGFR1) and the obligatory coreceptor βKlotho (KLB). This review is focused on various FGF21-class molecules, their molecular designs and the preclinical and clinical activities. The therapeutic utility of this class of molecules is being actively investigated in clinical trials for the treatment of type 2 diabetes and non-alcoholic steatohepatitis (NASH). The metabolic actions of FGF21-class proteins in obese mice are attributed to stimulation of brown fat thermogenesis and increased secretion of adiponectin. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.Fibroblast growth factor 21 (FGF21) analogs and FGF21 receptor agonists (FGF21RAs) that mimic FGF21 ligand activity constitute the new “FGF21-class” of anti-obesity and anti-diabetic molecules that improve insulin sensitivity, ameliorate hepatosteatosis and promote weight loss. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The FGFR3 gene is mapped to the HD region on chromosome 4p16.3. This gene encodes a member of the fibroblast growth factor receptor(FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. (Fibroblast Growth Factor Receptor 3 (FGFR3))įGFR3 antibody, LOC100034114 antibody, ACH antibody, CD333 antibody, CEK2 antibody, HSFGFR3EX antibody, JTK4 antibody, FR3 antibody, Fgfr-3 antibody, Flg-2 antibody, HBGFR antibody, Mfr3 antibody, sam3 antibody, fc27h01 antibody, wu:fc27h01 antibody, fibroblast growth factor receptor 3 antibody, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog antibody, FGFR3 antibody, fgfr3.S antibody, Fgfr3 antibody, fgfr3 antibodyįibroblast growth factor receptor 3, also known as CD333, is a protein that in humans is encoded by the FGFR3 gene. It can also be aliquotted and stored frozen at -20 ☌ for a longer time. After reconstitution, at 4☌ for one month. This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.Īt -20☌ for one year. Optimal dilutions should be determined by end users.Īntibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.Īdd 0.2 mL of distilled water will yield a concentration of 500 μg/mL.Įach vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Notes: Tested Species: Species with positive results. ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Rat IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
Protein Name: Fibroblast growth factor receptor 3Ī synthetic peptide corresponding to a sequence at the N-terminus of human FGFR3(110-129aa RQRLTQRVLCHFSVRVTDAP), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.
Gene Name: fibroblast growth factor receptor 3 Rabbit IgG polyclonal antibody for Fibroblast growth factor receptor 3(FGFR3) detection. Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) Immunofluorescence (fixed cells) (IF/ICC) Immunohistochemistry (Frozen Sections) (IHC (fro)) Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) Immunofluorescence (Paraffin-embedded Sections) (IF (p)) Immunofluorescence (Cultured Cells) (IF (cc))
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